Predictive approaches for drug combination discovery in cancer

Integrated Computational and Experimental Approaches for Accelerated Drug Combination Discovery and Development : Applications in Cancer Pharmacology

Kashif, M. 2015. Integrated Computational and Experimental Approaches for Accelerated Drug Combination Discovery and Development. Applications in Cancer Pharmacology. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1073. 58 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9177-2. Today the norm in modern cancer treatment is to use different form...

Combination Drug Delivery Approaches in Metastatic Breast Cancer

Disseminated metastatic breast cancer needs aggressive treatment due to its reduced response to anticancer treatment and hence low survival and quality of life. Although in theory a combination drug therapy has advantages over single-agent therapy, no appreciable survival enhancement is generally reported whereas increased toxicity is frequently seen in combination treatment especially in chemo...

Hunting for predictive computational drug-discovery models.

The Keystone Symposium on Computer-Aided Drug Design was held at Steamboat Springs (CO, USA), from March 29th to the 3rd of April, 2008. The organizers brought together approximately 180 participants, representing a cross-section of viewpoints from academia and the pharmaceutical industry. Since it is a young discipline, it was a privilege to have a keynote introduction from one of the original...

Net present value approaches for drug discovery

Three dedicated approaches to the calculation of the risk-adjusted net present value (rNPV) in drug discovery projects under different assumptions are suggested. The probability of finding a candidate drug suitable for clinical development and the time to the initiation of the clinical development is assumed to be flexible in contrast to the previously used models. The rNPV of the post-discover...

Computational and Structural Approaches in Drug Discovery